Adipose – Derived Mesenchymal Stem Cells

Adipose – Derived Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are a subset of non-hematopoietic adult stem cells that originate from the mesoderm. MSCs are able to self-renew and differentiate into multiple lineages including not only mesoderm lineages, such as chondrocytes, osteocytes and adipocytes, but also ectodermic cells and endodermic cells. MSCs have shown promise in regenerative medicine including peripheral arterial disease. Although MSCs are present in most tissues including bone marrow and adipose tissue, they exist at low levels. To harvest sufficient MSCs to manufacture a cellular therapy product it is therefore necessary to expand cell numbers in vitro.

Rexgenero’s adipose-derived mesenchymal stem cell product REX-002 has demonstrated some promise in CLI and is currently under development in a phase I/II clinical trial.